College Football Week 10: Games, Odds & Stakes

**College Football Week 10: Playoff Dreams and Fierce Rivalries Take Center Stage**

College football’s Week 10 slate on Saturday, November 4th, promises high drama and significant implications across the national landscape, with several top-25 clashes poised to reshape conference races and the College Football Playoff picture. From a de facto SEC West championship to the potential final chapter of a storied Big 12 rivalry, fans can expect intense action and potential upsets.

One of the marquee matchups sees the No. 8 Alabama Crimson Tide (7-1 overall, 5-0 SEC) hosting the No. 13 LSU Tigers (6-2, 4-1 SEC) at Bryant-Denny Stadium in Tuscaloosa. Kicking off at 7:45 p.m. ET on CBS, this game is largely considered the deciding factor for the SEC West division title. Alabama, undefeated in conference play since an early-season stumble, has found its stride behind quarterback Jalen Milroe, while LSU’s potent offense, led by Heisman-contending quarterback Jayden Daniels, has put up massive numbers. The Crimson Tide enters as a 3-point favorite, with the Over/Under set at 60.5 points. LSU famously took down Alabama in a thrilling overtime victory last season in Baton Rouge, adding a strong revenge narrative for Nick Saban’s squad.

Earlier in the day, at 3:30 p.m. ET on ABC, the “Bedlam” rivalry delivers what could be its final installment as a Big 12 conference game, with No. 19 Oklahoma (7-1, 4-1 Big 12) visiting Oklahoma State (6-2, 4-1 Big 12) in Stillwater. Both teams are firmly in the thick of the Big 12 title hunt, making this clash pivotal for their championship aspirations. Adding to the intrigue, Oklahoma State has surprisingly dominated recent matchups, winning five of the last seven meetings, including last year’s contest. The Sooners, led by quarterback Dillon Gabriel, are favored by 6 points, and the total points line is 61.5, suggesting a high-scoring affair.

Also within the hotly contested Big 12, No. 23 Kansas State (6-2, 4-1 Big 12) travels to Austin, Texas, to face No. 7 Texas (7-1, 4-1 Big 12) at Darrell K Royal-Texas Memorial Stadium. That game starts at 12 p.m. ET on FOX. Texas, fresh off a bye week and still harboring College Football Playoff hopes, absolutely needs this win to maintain pace in the Big 12. However, Kansas State, the reigning Big 12 champions, has historically performed well against the Longhorns, winning five of their last seven meetings. Texas is a 3.5-point favorite here, with the Over/Under at 57.5.

In the SEC, the undefeated No. 2 Georgia Bulldogs (8-0, 5-0 SEC) host the surprising No. 12 Missouri Tigers (7-1, 3-1 SEC) in Athens at Sanford Stadium at 3:30 p.m. ET on CBS. While Georgia is a hefty 15-point favorite with a 55-point Over/Under, Missouri under coach Eli Drinkwitz has defied expectations this season and nearly pulled off a massive upset against the Bulldogs last year. Led by quarterback Brady Cook, Mizzou’s offense will test Georgia’s formidable defense.

Out on the West Coast, a crucial Pac-12 matchup features No. 5 Washington (8-0, 5-0 Pac-12) visiting No. 24 USC (7-2, 5-1 Pac-12) at the Los Angeles Memorial Coliseum. This 7:30 p.m. ET game on ABC is vital for Washington’s perfect season and playoff aspirations, while USC, after recent struggles, looks to salvage its conference championship hopes and reassert its defensive prowess. The game also presents a Heisman Trophy spotlight for Washington’s Michael Penix Jr. and USC’s Caleb Williams. Washington is favored by 3 points, and this game boasts the highest projected score of the week with an Over/Under of 76.5 points, indicative of the offensive firepower on both sides.

Finally, at 12 p.m. ET on ABC, No. 20 Notre Dame (6-2) travels to Clemson’s Memorial Stadium in Clemson, South Carolina, to face the Clemson Tigers (4-4, 2-4 ACC). Both historic programs are looking to make a statement late in the season, with Clemson aiming to recover from a disappointing start to their campaign. This is expected to be a defensive battle, with Clemson favored by 3 points in what’s projected as a lower-scoring affair, reflected in an Over/Under of just 44.5 points. A win for Notre Dame would keep their New Year’s Six bowl hopes alive, while Clemson desperately needs a signature victory to regain momentum.